My game uses tiled, and right now I'm trying to decide how the game will register interactable objects. The game uses separate game states for each location, so I was thinking when the player interacts, it can just check his X and Y accordingly and match it that way, but I want to know if this is the most efficient way of doing it beforehand. What do you guys think?

Do you have a class for tiles and interactables?  I'd give the tile class a variable assigned to the interactable class, then if you try to interact, check to see if that tile's interactable is null, if not proceed.